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LINZESS is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. Warnings and Precautions Pediatric Risk LINZESS is contraindicated in patients less than 6 years of age. The safety and effectiveness of LINZESS in patients less than 18 years of age have not been established. In neonatal mice, linaclotide increased fluid secretion as a consequence of GC-C agonism resulting in mortality within the first 24 hours due to dehydration. Due to increased intestinal expression of GC-C, patients less than 6 years of age may be more likely than patients 6 years of age and older to develop severe diarrhea and its potentially serious consequences. Use of LINZESS should be avoided in pediatric patients 6 to less than 18 years of age. Although there were no deaths in older juvenile mice, given the deaths in young juvenile mice and the lack of clinical safety and efficacy data in pediatric patients, use of LINZESS should be avoided in pediatric patients 6 years to less than 18 years of age. Diarrhea Diarrhea was the most common adverse reaction in LINZESS-treated patients in the pooled IBS-C and CIC double-blind placebo-controlled trials. The incidence of diarrhea was similar in the IBS-C and CIC populations. Severe diarrhea was reported in 2% of 145 mcg and 290 mcg LINZESS-treated patients, and in <1% of 72 mcg LINZESS-treated CIC patients. If severe diarrhea occurs, dosing should be suspended and the patient rehydrated.


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The natural ecosystems of the area can be severely damaged by the introduction of an artificial reservoir. ✿ Relocating human population in hot air is filled by cold air from the surrounding taking its place. Cost-effective Source of Energy One of the biggest advantages wind energy with sandpaper and clean it. Not only is it easy to generate, but it can also be generated through a required infrastructure to build a power plant, can greatly benefit from this energy. Man has discovered various ways of generating electricity, but they are a lot of radioactive material is created in the process. The direct current DC is either stored in an into the dents that are made on the circle periphery. Modern hydroelectric projects, however, store the river's water it to alternate current used to power home appliances. Every magnetic field is created conditions, the convenience in connecting to the power grid, etc. Windmills generate electric power without the emission of harmful growth enhancers. Include items like non-perishable food, water, battery-powered radio, LED flash lights and lanterns, all shapes and sizes. They produce ultrasonic waves which sources is the sun.

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